I can not speak for others, just for myself. I have been in constant excruciating pain from my neck down for many years. Quality of life zero. Spending most of my time either in bed or my recliner. Only way to get anything done is by taking pain meds. Which never take the pain away, just take the edge off. After taking Immunocal for 2 weeks there is a definite improvement. Much more energy, less pain, more zest for life. I will keep you posted as time goes by; and the taste is delicious in orange juice.